Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors
Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs) embedded in the nuclear envelope.About 30 different Clearance proteins (nucleoporins, nups) arrange around a central eightfold rotational axis to build the modular NPC.Nup188 and Nup192 are related and evolutionary conserved, large nucleoporins that are part of the NPC scaffol